Calibrin®-Z Excels in Broiler Study Comparing Mycotoxin-Targeting Feed Additives

Calibrin®-Z logo and poultry farm infographic.

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Mycotoxin-contaminated feed is a constant challenge for poultry producers, made worse if environmental conditions favor the rapid growth of mycotoxin-producing fungi in the field or during storage. And if multiple mycotoxins have contaminated the feed, it can create a synergistic, or additive, effect, amplifying each mycotoxin’s negative outcome on poultry production.

Calibrin®-Z Binds Multiple Mycotoxins and More

Mitigating the effects of mycotoxin-contaminated feed is essential, because whether the effects on poultry are mild (due to long-term low-level exposure) or severe (from a high-level challenge), a decrease in performance (and profits) is usually inevitable. To diminish the effects of mycotoxicosis, poultry diets often include feed additives that target mycotoxins. Examples of these feed additives include Calibrin®-Z (our mineral-based biotoxin binder), yeast cell wall preparations, enzyme-based products and algae-based additives.

Unlike other mineral-based products, Calibrin-Z undergoes specifically tailored, proprietary thermal processing that promotes the binding of a broad spectrum of biotoxins, including polar and nonpolar mycotoxins. Calibrin-Z also binds bacterial exotoxins and endotoxins, such as those produced by Clostridium perfringens and Escherichia coli, to help combat enteric disease.

University of Missouri Study Compares Feed Additive Performance

To evaluate the performance of products marketed to mitigate mycotoxin-contaminated feed, researchers at the University of Missouri (Columbia, MO) evaluated the ability of commercial feed additives to reduce the combined toxic effects of concurrent aflatoxin B1 and fumonisin B1 exposure in poultry. In the 21-day feeding trial, 144 broiler chicks were randomly assigned to six treatment groups with 24 birds in each group (Table 1). Statistical significance for treatment comparisons was set at P < 0.10.

Table 1. Dietary Treatments by Group

Calibrin®-Z Aflatoxin B1, Fumonisin B1 and feed additive chart.

Similar Body Weight Gain for Calibrin-Z and Unchallenged Control Birds

The results showed that as expected, mycotoxin-contaminated feed significantly reduced broiler weight gain (Figure 1). However, Calibrin-Z was able to mitigate this performance loss. Birds fed the mycotoxin-challenged diet and Calibrin‑Z recorded statistically similar body weight gain as the non-challenged control birds (P = 0.35). This performance recovery was not seen to the same extent in challenged birds receiving the algae-, enzyme- or yeast cell wall‑based products, as birds from these groups gained significantly less weight than the non-challenged control group birds (P < 0.10). The weight gain of Calibrin-Z-supplemented birds was also 6 percent greater than the weight gain of enzyme-supplemented birds, 11 percent greater than the yeast cell wall group and 19 percent greater than the algae-based product group.

Calibrin®-Z body weight gain chart.
Different letters indicate a significant difference between groups (P < 0.10). Figure 1. Body weight gain of birds fed a diet containing two mycotoxins plus Calibrin-Z was statistically similar to that of birds receiving a diet free of mycotoxins.

Calibrin-Z Numerically Improved Feed Conversion

Feeding Calibrin-Z to mycotoxin-challenged broilers improved feed conversion by up to 10 points compared to diets supplemented with enzyme, yeast cell wall or algae-based products (Figure 2).  While not a statistical difference in this trial, these results represent a significant numerical difference in broiler production.

Calibrin®-Z feed conversion ratio chart.
Figure 2. All groups had statistically similar feed conversion, with Calibrin-Z numerically improving feed conversion compared to all groups except the unchallenged control.

This study showed that adding Calibrin-Z to aflatoxin- and fumonisin-contaminated feed enabled broiler chickens to maintain weight gain and feed conversion similar to birds fed a mycotoxin-free diet. The other commercial products did not improve bird performance to the same extent as Calibrin-Z in this study, demonstrating the production advantage Calibrin-Z delivers by binding multiple biotoxins and improving intestinal tract health. For more information on this study, or on the health and productivity benefits of adding Calibrin‑Z to your birds’ rations, contact us.

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