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Source: Xue H, Wang D, Hargis BM, Tellez-Isaias G. Research Note: Virulence gene downregulation and reduced intestinal colonization of Salmonella enterica serovar Typhimurium PHL2020 isolate in broilers by a natural antimicrobial (NeutraPath™). Poultry Science. 2022 Mar 7:101822. https://doi.org/10.1016/j.psj.2022.101822.
Reducing intestinal Salmonella colonization in poultry is a key strategy in controlling Salmonella contamination of poultry products and, in turn, lowering the incidence of salmonellosis in people. Subtherapeutic levels of antibiotic growth promoters (AGP) can help control enteric pathogens like Salmonella, but restrictions in AGP use have created the need for antibiotic-free methods of reducing enteric pathogens in poultry.
A natural mineral-based feed additive that has previously shown action against Salmonella prevalence is NeutraPath® — a select blend of essential oils, fatty acids and a thermally processed enterosorbent mineral. A recent Poultry Science study investigated the antimicrobial effects of NeutraPath against Salmonella enterica serovar Typhimurium strain PHL2020 (ST-PHL2020) and the effects of NeutraPath on ST-PHL2020 virulence gene expression.
The study showed that NeutraPath exhibited a potent antimicrobial effect against ST-PHL2020 and reduced its intestinal colonization. NeutraPath also modulated ST-PHL2020 virulence network development by downregulating mRNA expression of key virulence genes and blocking expression of downstream effectors involved in Salmonella invasion. Together, the results show that NeutraPath has the potential to reduce ST-PHL2020 intestinal colonization in broilers and downregulate key ST-PHL2020 virulence genes.