Animal feed that’s contaminated with mycotoxins can have a wide range of adverse effects on animal health and performance. In most cases, the effects of mycotoxicosis can be insidious, resulting from exposure to low levels of the toxins over long periods of time, eventually impairing immune system function and leaving animals susceptible to disease.
Select Your Species
Poultry
Swine
Dairy
Companion Animal
Aquaculture
Select Your Species
Poultry
Swine
Dairy
Companion Animal
Aquaculture
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Multiple Mycotoxins Create an Additive Toxic Effect
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Many Factors Influence the Extent of Mycotoxin Toxicity
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Most Mycotoxin Binders Only Bind Polar Mycotoxins
Multiple mycotoxins can contaminate feed, creating a synergistic, or additive, effect, amplifying the negative effects of each mycotoxin. Signs of mycotoxicosis in poultry can range from mild to severe, depending on the specific mycotoxin involved, the concentration, the duration of exposure, health status of the bird and environmental factors.
Amlan Feed Additives Bind Polar and Nonpolar Mycotoxins
Mycotoxins are classified as either hydrophilic/polar molecules (for example, aflatoxin) or hydrophobic/nonpolar molecules (for example, zearalenone). The specific structural properties of our unique mineral technology, together with our proprietary thermal-processing method optimized for each product application, are why Calibrin®-Z and other Amlan feed additives can bind polar and nonpolar mycotoxins.
Source: Amlan International.
WEIGHT GAIN, g, Day 0-21
1 PPM AFL + 100 PPM FUM
Weight gain of mycotoxin-challenged broilers (540 total birds) fed different anti-mycotoxin additives. Source: SAMITEC, Santa Maria, Brazil.
Fungal Biotoxin Binding Using Observed Levels In Feed
(% Adsorbed)
Source: Trilogy Analytical Laboratory, USA.
Feed Conversion Ratio, DAY 0-21
1 PPM AFL + 100 PPM FUM
Feed conversion ratio of mycotoxin-challenged broilers (540 total birds) fed different anti-mycotoxin additives. Source: SAMITEC, Santa Maria, Brazil.
Calibrin-Z Binds Multiple Mycotoxins to Improve Broiler Performance
Calibrin-Z is a low-dose, mineral-based biotoxin binder that protects poultry from mycotoxins that reduce health and performance. Calibrin-Z effectively binds polar and nonpolar mycotoxins and improves the performance and health of broilers challenged with mycotoxin-contaminated feed.
- Binds polar mycotoxins: aflatoxin, ergotamine, ergovaline and cyclopiazonic acid
- Binds nonpolar mycotoxins: T-2 toxin, fumonisin, ochratoxin and zearalenone
- Improves feed conversion and weight gain of broilers fed mycotoxin-contaminated diets
BioInsights Minimizes Mycotoxin-Contaminated Feed Risks
Amlan BioInsights Mycotoxin Diagnostic Service helps minimize the effects of mycotoxin-contaminated feed by providing on-site feed ingredient testing that accurately identifies and quantifies mycotoxins within minutes. BioInsights then recommends the most effective dose of Calibrin-Z to mitigate the mycotoxin contamination.
Other Amlan Products That Help Improve Performance and Intestinal Health
Calibrin-Z can be used in combination with natural, patented Varium® that can reduce challenges from pathogenic bacteria and their toxins, strengthen the intestinal barrier and safely stimulate intestinal immunity. NeutraPath®, a natural pathogen control feed additive, synergistically works with Calibrin-Z to protect bird health and performance. It has bactericidal and bacteriostatic effects and can neutralize pathogen virulence factors.
Proven Natural Solutions for Mycotoxicosis
Independent research studies prove Calibrin-Z binds mycotoxins in addition to bacterial pathogens and their toxins. In addition, broilers fed aflatoxin- and fumonisin-contaminated feed that also contained Calibrin-Z had improved body weight gain and European efficiency index. Calibrin-A was also effective in protecting poultry against the detrimental effects of aflatoxin. Read some of our published mycotoxin research below.
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Mycotoxicosis Symptoms Can Vary in Severity
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Contamination From Multiple Mycotoxins Can Cause an Additive Toxic Effect
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Animal and Environmental Factors Influence Mycotoxin Toxicity
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Most Mycotoxin Binders Bind Polar, but Not Nonpolar, Mycotoxins
Signs of mycotoxicosis in swine can range from mild to severe, depending on the particular mycotoxins present, their concentration, the exposure duration, the animal’s health status and various environmental factors. When multiple mycotoxins contaminate feed, they create synergistic or additive effects, which amplifies the negative effects of each mycotoxin.
Amlan’s Mineral-Based Products Bind Polar and Nonpolar Mycotoxins
Mycotoxins are classified as either polar/hydrophilic molecules (for example, aflatoxin) or nonpolar/hydrophobic molecules (for example, zearalenone). The unique mineral technology in Amlan products has specific structural properties that, together with our proprietary thermal-processing method that is optimized for each product application, is why Calibrin-Z and other Amlan feed additives can bind polar and nonpolar mycotoxins.
Source: Amlan International.
Fungal Biotoxin Binding Using Observed Levels in Feed
(% Adsorbed)
Source: Trilogy Analytical Laboratory, USA.
In Vitro E. coli Heat Labile Toxin Adsorption
(% Adsorbed)
Source: USDA-ARS, Beltsville, MD.
In Vitro E. coli Shiga-Like Toxin Adsorption
(% Adsorbed)
Source: USDA-ARS, Beltsville, MD.
In Vitro C. perfringens Toxin Adsorption
(% Adsorbed)
Source: USDA-ARS, Beltsville, MD.
E. coli Endotoxin Binding
(% Adsorbed)
Source: Gilbraltar Laboratories, Fairfield, NJ.
Calibrin®-Z Moderates the Mycotoxicosis Risk
Calibrin-Z is a broad-spectrum biotoxin binder that reduces the risk of mycotoxicosis in swine. By effectively binding mycotoxins (like aflatoxin and zearalenone), Calibrin-Z can help improve the performance and health of swine challenged with mycotoxin-contaminated feed.
- Binds polar mycotoxins: aflatoxin, ergotamine, ergovaline and cyclopiazonic acid
- Binds nonpolar mycotoxins: T-2 toxin, fumonisin, ochratoxin and zearalenone
- Also binds bacterial pathogens and their toxins (for example, E. coli and Salmonella)
Quantify Mycotoxins in Feed with BioInsights
Our BioInsights Mycotoxin Diagnostic Service helps reduce the problems caused by mycotoxin-contaminated feed by testing feed ingredients on-site to characterize and quantify mycotoxins in the feed quickly and accurately. BioInsights then suggests the most efficacious Calibrin-Z dose to abate the mycotoxin contamination.
Other Amlan Products that Help Improve Swine Performance and Intestinal Health
Calibrin-Z can be used in combination with natural, patented NeoPrime® which promotes swine intestinal health and gently primes intestinal immunity. NeutraPath®, a natural pathogen-control product,works synergistically with Calibrin-Z to protect swine health and performance, as it has bactericidal and bacteriostatic effects and can neutralize pathogen virulence factors.
Proven Natural Solutions for Mycotoxicosis
Independent research studies have shown Calibrin-Z binds mycotoxins in addition to bacterial pathogens and their toxins.
Effect on hepatonephric organs, serum metabolites and oxidative stress in post-weaning piglets fed purified zearalenone-contaminated diets with or without Calibrin-Z.
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Multiple Mycotoxins in Feed Can Cause an Additive Toxic Effect
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Cow Health and Environmental Factors Influence Mycotoxin Toxicity
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Most Mycotoxin Binders Bind Polar, Not Nonpolar, Mycotoxins
Ruminants are susceptible to the effects of mycotoxin-contaminated feed. They can develop mycotoxicosis health issues and have reduced performance — particularly if the mycotoxin concentration in the feed is high.
Amlan’s Mineral-Based Products Bind Polar and Nonpolar Mycotoxins
Mycotoxins are either polar/hydrophilic molecules (for example, aflatoxin) or nonpolar/hydrophobic molecules (for example, zearalenone and fumonisin). Our unique mineral technology has specific structural properties that, when coupled with our proprietary thermal processing optimized for each product application, allow Calibrin-Z and other Amlan products to bind polar and nonpolar mycotoxins, helping to prevent mycotoxin absorption.
Source: Amlan International.
Fungal Biotoxin Binding Using Observed Levels in Feed
(% Adsorbed)
Source: Trilogy Analytical Laboratory, USA.
In Vitro E. coli Heat Labile Toxin Adsorption
(% Adsorbed)
Source: USDA-ARS, Beltsville, MD.
In Vitro E. coli Shiga-Like Toxin Adsorption
(% Adsorbed)
Source: USDA-ARS, Beltsville, MD.
In Vitro C. perfringens Toxin Adsorption
(% Adsorbed)
Source: USDA-ARS, Beltsville, MD.
E. coli Endotoxin Binding
(% Adsorbed)
Source: Gilbraltar Laboratories, Fairfield, NJ.
Calibrin®-Z Moderates the Mycotoxicosis Risk
Calibrin-Z is a broad-spectrum biotoxin binder that reduces the risk of mycotoxicosis in dairy. By effectively binding mycotoxins (like aflatoxin and zearalenone), Calibrin-Z can help improve the performance and health of dairy challenged with mycotoxin-contaminated feed.
- Binds polar mycotoxins — aflatoxin, ergotamine, ergovaline and cyclopiazonic acid
- Binds nonpolar mycotoxins — T-2 toxin, fumonisin, ochratoxin and zearalenone
- Also binds bacterial pathogens and their toxins (for example, E. coli and Salmonella)
BioInsights: Quick and Accurate Mycotoxin Testing
Help protect your animals and your business with our BioInsights Mycotoxin Diagnostic Service. This easy on-site test lets you know quickly and accurately if feed ingredients contain mycotoxins, including which mycotoxins and their quantity. Our service can then recommend the appropriate Calibrin-Z dose to combat the mycotoxin contamination.
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Multiple Mycotoxins in Feed Can Cause an Additive Toxic Effect
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Pet Health and Environmental Factors Influence Mycotoxin Toxicity
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Most Mycotoxin Binders Only Bind Polar Mycotoxins
Pet food is routinely tested for mycotoxin contamination during manufacturing; however, in rare cases mycotoxin-contaminated pet food products can still make it to market. Mycotoxins can cause significant health issues for pets, including mortality if mycotoxins levels are high or animals have underlying issues. A healthy gastrointestinal tract can help companion animals mitigate a mycotoxin challenge.
Minimize Mycotoxin-Contaminated Feed Risks With BioInsights
BioInsights Mycotoxin Diagnostic Service provided by Amlan International can help reduce the risk of mycotoxicosis in companion animals. With fast and accurate testing of feed ingredients on-site, BioInsights can determine which mycotoxins are present and in what quantity.
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Multiple Mycotoxins in Feed Can Cause an Additive Toxic Effect
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Fish and Shrimp Health, Age and Environmental Factors Influence Mycotoxin Toxicity
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Most Mycotoxin Binders Bind Polar, but Not Nonpolar, Mycotoxins
Aquatic species can develop mycotoxicosis when feed is contaminated with a single mycotoxin or multiple mycotoxins that result in additive toxic effects. The severity of the disease depends on the species, age and environmental conditions, but mycotoxicosis generally causes poor growth, increased disease rates, hepatopancreatic issues in shrimp and, in some cases, mortality.
Amlan Products Bind Polar and Nonpolar Mycotoxins
Mycotoxins are either polar/hydrophilic molecules (for example, aflatoxin) or nonpolar/hydrophobic molecules (for example, zearalenone and fumonisin). Our unique mineral technology has specific structural properties that, when coupled with our proprietary thermal processing, allow Calibrin-Z to bind polar and nonpolar mycotoxins, helping to prevent mycotoxin absorption.
Source: Amlan International.
Fungal Biotoxin Binding Using Observed Levels in Feed
(% Adsorbed)
Source: Trilogy Analytical Laboratory, USA.
In Vitro Vibrio parahaemolyticus Toxin Adsorption
(% Adsorbed)
Source: National Cheng Kung University, Taiwan.
Reduce Mycotoxin Effects with Calibrin®-Z
Our bacterial toxin and mycotoxin binder Calibrin-Z helps lower mycotoxicosis risks in aquaculture species. By adsorbing polar and nonpolar mycotoxins, Calibrin-Z can improve the growth and health of aquaculture species by reducing the negative effects of mycotoxicosis.
- Binds polar mycotoxins — aflatoxin, ergotamine, ergovaline and cyclopiazonic acid
- Binds nonpolar mycotoxins — T-2 toxin, fumonisin, ochratoxin and zearalenone
- Also binds bacterial pathogens and their toxins (for example, Vibrio parahaemolyticus)
Consider BioInsights Mycotoxin Diagnostic Service
If you’re concerned about feed ingredients being contaminated with mycotoxins, BioInsights can help. Our on-site testing service provides accurate and fast analysis of which mycotoxins are in the feed and their quantity. BioInsights can then suggest the Calibrin-Z dose that is the most effective for your situation.
Learn More About Controlling Mycotoxicosis in Poultry by Contacting Your Nearest Amlan Rep 
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