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Varium® Improves Performance in Commercial Broilers Compared to an Antibiotic Growth Promoter

Varium Product Blog

Varium was developed to provide poultry producers with a product to improve production by optimizing gut health. One of the ways this can be shown is by improvements in feed conversion. Because feed costs are such a large part of the cost of poultry production, any improvement in feed conversion can have a big impact on the bottom line. Additionally, decreasing the amount of feed used to produce a kilogram of meat increases the sustainability of the operation, which is very important in today’s world.

Varium, available in select international markets, has multiple modes of action to increase its ability to improve performance. It was designed to protect against biotoxins ​in the lumen of the gastrointestinal tract and keep them from entering the body, to energize the epithelial cells that line the intestine, and help the immune system prepare to respond to antigens. ​Over the years numerous controlled experiments have shown that Varium improves feed conversion under a variety of conditions. A meta-analysis of this research was presented at the Poultry Science Association’s 2nd Latin American Scientific Conference in Campinas, São Paulo, Brazil. This summary of multiple experiments showed that feeding Varium resulted in broiler performance that was equal to that obtained when an antibiotic growth promoter was fed, this was seen both in birds that were challenged with the bacterium Clostridium perfringens to induce necrotic enteritis and in unchallenged birds. When both the antibiotic and Varium were fed together it improved the feed conversion ratio even more (Figure 1).

Graph of relative FCR to control

Figure 1. Varium improved Feed Conversion Ratio (FCR) compared to unchallenged or challenged control, equal to the antibiotic growth promoter (AGP).

Since that time, information from the field has shown that feeding Varium resulted in less damage to the intestine of commercial broilers and improved villi height/crypt depth, which correlated to improved overall feed conversion (Lima, Peru).

In 2022, a large commercial study was run in southern Brazil. The study used approximately 180,000 broilers from three farms with each farm feeding one house a control diet with their standard feed containing a mycotoxin binder and enramycin, an antibiotic used as a feed additive to prevent necrotic enteritis. A second house had those ingredients removed and 0.1% Varium was added. The chicks that were supplied to the farms for evaluation were from breeders of the same age. Every week a sample weight was measured in each barn and mortalities were tabulated. Birds were harvested at 47.29 days for the Control birds and 47.17 days for the Varium fed birds (Figure 2). With a daily weight gain of 69.60 g for the Control birds and 70.62 g for the Varium fed birds.

Graph of body weight in kilograms

Figure 2. Body weight (kg) for broilers fed 0.1% Varium compared to broilers fed feed containing a mycotoxin binder and the antibiotic enramycin.

Weekly mortality, cumulative mortality, and transport mortality were all lower when birds were fed Varium compared to those fed the antibiotic (Figure 3). Overall feed conversion was 1.717 for the Control birds and 1.671 for the birds fed Varium; an advantage for birds fed Varium of 4.6 points.

Graph of cumulative mortality percentage by week

Figure 3. Mortality was lower for birds fed Varium each week and cumulatively by week. Final mortality included birds that died during transportation to harvest.

Feed conversion was 1.717 for the Control birds and 1.671 for the Varium fed birds, an advantage of 4.6 points (Figure 4). When the feed conversion was adjusted to a common ending weight of 3.25 kg adjusted feed conversion was 1.706 for the Control birds and 1.643 for the Varium fed birds, an advantage of 6.3 points for the Varium fed birds.

Graph of feed conversion

Figure 4. Feed conversion improved when broilers were fed Varium versus an antibiotic, both for overall or when adjusted to a final weight of 3.25 kg.

The 2022 Brazilian study shows that feeding Varium can improve efficiencies and performance, which are critical to increasing profits. In this case, the added annual profit for a producer processing 1 million birds per week would equate to approximately USD 6 million. Using an estimated price for the control diet of USD 375 and USD 380 for the Varium diet, the return on the cost of adding Varium vs the antibiotic control diet is approximately 4 to 1.

To learn more about improved performance with Varium and how to request a field trial, contact your local Amlan representative.

NeutraPath®: Natural Pathogen Control Using Feed Ingredient Synergy

NeutraPath biology with swine in background.

The control of pathogens and disease is a recurring challenge for livestock and poultry producers, whether they use conventional or antibiotic-free production systems. Amlan is tackling the challenge of disease prevention with the development of a natural feed additive that combines multiple feed ingredients that help reduce bacterial pathogens and their toxins. NeutraPath®, a natural feed additive for all species, reduces the pathogenic bacterial load and colonization, while also improving intestinal health and structural integrity, all of which contribute to improved bird performance and production economics.

NeutraPath (available in select international markets) features a unique blend of essential oils, fatty acids and Amlan’s proprietary mineral technology. The product’s potent antibacterial formula was engineered to neutralize bacterial toxins, destabilize bacterial cell membranes and disrupt cell-to-cell communication between pathogenic bacteria, all while also improving intestinal health.

NeutraPath has been shown in various studies to have antibacterial properties against a variety of gram-negative and gram-positive bacterial pathogens. By reducing pathogenic bacterial intestinal colonization, NeutraPath improved feed conversion and intestinal health and reduced bacterial diarrhea, necrotic enteritis lesions, and mortality. Here we present a summary of some of the NeutraPath research, including data published in peer reviewed journals or presented at international scientific meetings. Contact info@amlan.com for more details of these studies.

Dual Effects: Disarming Pathogens and Reducing Their Prevalence
The antibacterial activity of NeutraPath against a variety of production-limiting pathogen species was demonstrated in both poultry and swine studies. In various broiler studies, birds challenged with either Salmonella enterica serovar Heidelberg, Salmonella enterica serovar Typhimurium or Clostridium perfringens had decreased prevalence and bacterial load of the pathogen in the ceca, cecal tonsils, cecal contents or cloacal swabs compared with the challenged control. There was also a fourfold reduction of alpha-toxin levels in the cecal contents of broilers challenged with C. perfringens compared with the challenged control (Figure 1).

Alpha-toxin levels info graphic.
Figure 1: Alpha-toxin levels in the cecal contents of broilers challenged with C. perfringens. Source: Southern Poultry Research, Inc., Athens, GA. 128 total birds.

In swine orally inoculated with F18+ enterotoxigenic E. coli (ETEC), feeding NeutraPath reduced the frequency of diarrhea, indicating a greater resistance to disease (He et al., 2022). Changes in the fecal microbiome and ileal mucosa microbiota composition suggested NeutraPath also helps maintain a desirable balance in the intestinal microbial ecosystem.

Collectively, these studies indicate that NeutraPath can selectively modulate gut microbiota homeostasis via exerting potent antibacterial effects against enteric pathogenic bacteria while preserving or promoting beneficial bacteria.

Healthier Swine and Poultry
The antibacterial effects of NeutraPath promote positive health benefits for poultry and swine. In broilers challenged with C. perfringens-induced necrotic enteritis in combination with Eimeria maxima infection, NeutraPath improved livability and necrotic enteritis-related lesion scores compared with challenged control birds (Figure 2). Additionally, using antibiotics instead of NeutraPath produced similar mortality rates and lesion scores as NeutraPath.

Mortality rates info graphic.
Lesion scores info graphic.
Figures 2 and 3: Necrotic enteritis-caused mortality rates and lesion scores in broilers. 240 total birds. Source: Southern Poultry Research, Inc. Athens, GA.

The data from the broiler studies indicate that NeutraPath can be used to help manage C. perfringens-induced necrotic enteritis in broilers. As mentioned earlier, NeutraPath was also shown to decrease the incidence of severe diarrhea in weaned pigs challenged with Enterotoxigenic E. coli (ETEC).

Enhanced Production Performance
NeutraPath was also able to improve production parameters in poultry and swine. In a summary of four similarly designed broiler studies that experimentally induced necrotic enteritis, NeutraPath showed better performance than the challenged control group and performed similarly to antibiotic-treated birds (Table 1). The results of these studies show that NeutraPath was comparable to an antibiotic in improving performance of broilers challenged with necrotic enteritis.

Necrotic Enteritis-challenged broiler performance info graphic.
Table 1: Comparison of necrotic enteritis-challenged broiler performance. Source: Southern Poultry Research Inc., Athens, GA. Birds were challenged with C. perfringens at 2 weeks of age and grown to day 28.

In the swine ETEC challenge study, compared to the control, pigs fed NeutraPath demonstrated improved growth during the last two weeks of the study with improvements in feed efficiency during days 14 to 21 post-inoculation. These studies demonstrate that NeutraPath can enhance growth performance in broilers and swine challenged with production limiting pathogens.

In these studies, the synergism of NeutraPath ingredients worked well to reduce pathogenic bacterial colonization, improve health parameters and enhance production performance in swine and poultry. For more information on NeutraPath or to set up your own NeutraPath trial, contact info@amlan.com.

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